Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery

Title
Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery
Authors
최귀원권익찬김광명김선화이지영이상민민현수이장욱이태웅손세진유동길한문희박재형박기남이재영
Keywords
Ultrasound (US) imaging; Ultrasound contrast agent; Chemical gas-generating nanoparticle; Tumor targeting; Drug delivery
Issue Date
2016-11
Publisher
Biomaterials
Citation
VOL 108-70
Abstract
Although there is great versatility of ultrasound (US) technologies in the real clinical field, one main technical challenge is the compromising of high quality of echo properties and size engineering of ultrasound contrast agents (UCAs); a high echo property is offset by reducing particle size. Herein, a new strategy for overcoming the dilemma by devising chemical gas (CO2) generating carbonate copolymer nanoparticles (Gas-NPs), which are clearly distinguished from the conventional gas-encapsulated micro sized UCAs. More importantly, Gas-NPs could be readily engineered to strengthen the desirable in vivo physicochemical properties for nano-sized drug carriers with higher tumor targeting ability, as well as the high quality of echo properties for tumor-targeted US imaging. In tumor-bearing mice, anticancer drug-loaded Gas-NPs showed the desirable theranostic functions for US-triggered drug delivery, even after i.v. injection. In this regard, and as demonstrated in the aforementioned study, our technology could serve a highly effective platform in building theranostic UCAs with great sophistication and therapeutic applicability in tumor-targeted US imaging and US-triggered drug delivery. (C) 2016 Elsevier Ltd. All rights reserved.
URI
http://pubs.kist.re.kr/handle/201004/64934
ISSN
0142-9612
Appears in Collections:
KIST Publication > Article
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