Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting

Title
Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting
Authors
권익찬김광명김인산김경민오근상박달용이재영이범석김상윤윤순홍
Keywords
Combination therapy; Core/shell nanoparticles; Radiotherapy; Gold nanoparticles; Doxorubicin
Issue Date
2016-04
Publisher
Journal of controlled release
Citation
VOL 228, NO 28-149
Abstract
A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer. (C) 2016 Elsevier B.V. All rights reserved
URI
http://pubs.kist.re.kr/handle/201004/64954
ISSN
0168-3659
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KIST Publication > Article
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