Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer

Title
Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer
Authors
권익찬김광명최기영유동길엄우람V.G.Deepagan고혜원권승리이기라이준영이두성박재형
Keywords
Au-TiO2 nanocomposite; prolonged circulation; ultrasound; ROS; enhanced sonodynamic therapy
Issue Date
2016-10
Publisher
Nano letters
Citation
VOL 16, NO 10-6264
Abstract
Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photo dynamic therapy, the low quantum yield of the sonosensitizer such as TiO2 nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO2 nano composites (HAu-TiO2 NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO2 NCs to ultrasoUnd, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO2 NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for Cancer therapy.
URI
http://pubs.kist.re.kr/handle/201004/64971
ISSN
1530-6984
Appears in Collections:
KIST Publication > Article
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