Double-Layer Magnetic Nanoparticle-Embedded Silica Particles for Efficient Bio-Separation

Title
Double-Layer Magnetic Nanoparticle-Embedded Silica Particles for Efficient Bio-Separation
Authors
김세훈San KyeongCheolhwan JeongHoman KangHong-Jun ChoSung-Jun ParkJin-Kyoung YangHyung-Mo KimBong-Hyun JunYoon-Sik Lee
Issue Date
2015-11
Publisher
PLoS ONE
Citation
-12
Abstract
Superparamagnetic Fe3O4 nanoparticles (NPs) based nanomaterials have been exploited in various biotechnology fields including biomolecule separation. However, slow accumulation of Fe3O4 NPs by magnets may limit broad applications of Fe3O4 NP-based nanomaterials. In this study, we report fabrication of Fe3O4 NPs double-layered silica nanoparticles (DL MNPs) with a silica core and highly packed Fe3O4 NPs layers. The DL MNPs had a superparamagnetic property and efficient accumulation kinetics under an external magnetic field. Moreover, the magnetic field-exposed DL MNPs show quantitative accumulation, whereas Fe3O4 NPs single-layered silica nanoparticles (SL MNPs) and silica-coated Fe3O4 NPs produced a saturated plateau under full recovery of the NPs. DL MNPs are promising nanomaterials with great potential to separate and analyze biomolecules.
URI
http://pubs.kist.re.kr/handle/201004/65110
ISSN
1932-6203
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KIST Publication > Article
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