Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy
- Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy
- 권익찬; 김세훈; 김영선; 정근수; 이용덕; 강지수
- Issue Date
- Cancer letters
- VOL 374-43
- Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.
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