Toward Better Genetically Encoded Sensors of Membrane Potential

Title
Toward Better Genetically Encoded Sensors of Membrane Potential
Authors
브래들리 베이커마소드강복음Storace DouglasCohen, Lawrence BHughes, Thom
Issue Date
2016-05
Publisher
Trends in neurosciences
Citation
VOL 39, NO 5-289
Abstract
Genetically encoded optical sensors of cell activity are powerful tools that can be targeted to specific cell types. This is especially important in neuroscience because individual brain regions can include a multitude of different cell types. Optical imaging allows for simultaneous recording from numerous neurons or brain regions. Optical signals of membrane potential are useful because membrane potential changes are a direct sign of both synaptic and action potentials. Here we describe recent improvements in the in vitro and in vivo signal size and kinetics of genetically encoded voltage indicators (GEVIs) and discuss their relationship to alternative sensors of neural activity.
URI
http://pubs.kist.re.kr/handle/201004/65188
ISSN
0166-2236
Appears in Collections:
KIST Publication > Article
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