Cyanidin 3-O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling

Title
Cyanidin 3-O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling
Authors
함정엽강기성이혜정이다혜
Keywords
Cyanidin 3-O-glucoside; Glucose response; Insulin secretion; Lonicera caerulea
Issue Date
2016-12
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 37-2018
Abstract
Cyaniding 3-O-glucoside is a flavonoid compound isolated from the fruits of the Lonicera caerulea. In the present study, we investigated the effects of L. caerulea extract and its active component cyaniding 3-O-glucoside on insulin release in INS-1 cells. L. caerulea extract and cyanidin 3-O-glucoside activated the secretion of insulin that lead to diminished glucose production in INS-1 cells. Cyanidin 3-O-glucoside also enhanced the phosphorylation of insulin receptor, insulin receptor substrate 1, and phosphoinositide 3-kinase protein expressions in INS-1 cells. These results suggest that cyanidin 3-O-glucoside is an active component of L. caerulea that enhances insulin production and activates insulin signaling.
URI
http://pubs.kist.re.kr/handle/201004/65199
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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