Facile Synthesis of 2-Amino-4-alkoxypyrimidines via Consecutive Nucleophilic Aromatic Substitution (S N Ar) Reactions

Title
Facile Synthesis of 2-Amino-4-alkoxypyrimidines via Consecutive Nucleophilic Aromatic Substitution (S N Ar) Reactions
Authors
조용서김주현민선준
Keywords
2-Amino-4-alkoxypyrimidines; Nucleophilic aromatic substitution; Regioselectivity; Alkoxy- lation; Amination
Issue Date
2016-12
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 37, NO 12-2008
Abstract
A transition-metal-free and regioselective synthesis of a series of 2-amino-4-alkoxypyrimidines is described. The SNAr alkoxylation of 2,4-dichloropyrimidines regioselectively provided 2-chloro-4-alkoxypyrimidines, which were subsequently subject to the second SNAr amination with cyclic amines in the presence of triethylamine at high temperature to afford 2-amino-4-alkoxypyrimidines in good overall yield.
URI
http://pubs.kist.re.kr/handle/201004/65222
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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