Modular delivery of CpG-incorporated lipid-DNA nanoparticles for spleen DC activation

Title
Modular delivery of CpG-incorporated lipid-DNA nanoparticles for spleen DC activation
Authors
주진오박해인Wei ZhangJan Willem de VriesAgnieszka Gruszka이명원Andreas Hermann곽민석안대로
Keywords
dendritic cells; immunology; adjuvants; nanomedicine; DNA nanotechnology
Issue Date
2017-01
Publisher
Biomaterials
Citation
VOL 115-89
Abstract
We introduce a versatile carrier system for in vitro and in vivo immune stimulation based on soft matter DNA nanoparticles (NPs). The incorporation of lipid-modified nucleotides into DNA strands enables the formation of micelles of uniform size. In a single self-assembly step, the micelles can be equipped with immune adjuvant (CpG) motifs and fluorescent probes. The immunological effects of CpG confined at the NP surface were studied in a comprehensive manner in animal experiments. Dose-dependent activation of spleen dendritic cells (DCs) by CpG-conjugated NP was observed, which was accompanied by the pronounced up-regulation of co-stimulatory molecule and cytokine production.
URI
http://pubs.kist.re.kr/handle/201004/65242
ISSN
0142-9612
Appears in Collections:
KIST Publication > Article
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