Korean red ginseng improves testicular ineffectiveness in aging rats by modulating spermatogenesis-related molecules

Title
Korean red ginseng improves testicular ineffectiveness in aging rats by modulating spermatogenesis-related molecules
Authors
김수남김진철Spandana Rajendra Kopalli차규민류지훈이상호정민식황석연이영주송희원김시관
Keywords
Korean red ginseng; sirtuin 1; aging; mTORC1; androgen; inhibitin; peroxiredoxin
Issue Date
2017-04
Publisher
Experimental gerontology
Citation
VOL 90-33
Abstract
Korean red ginseng (Panax ginseng Meyer) is known to rejuvenate testicular effectiveness and the sperm maturation process by regulating redox proteins in aged rats. This study was performed to investigate the effect of Korean red ginseng water extract (KRG-WE) on the expression level of spermatogenesis-related key biomolecules and sex hormone receptors as well as enzymes regulating oxidation, histone deacetylation, and growth-related activities in aged rat testis. KRG-WE (200 mg/kg) mixed with a regular pellet diet was administered to 12-month-old rats for 6 months (KRG-AC), whereas the young (YC, 2 months) and aged (AC, 12 months) controls received the vehicle only. The results showed that the expression levels of spermatogenesis-related key biomolecules (inhibin-α, nectin-2, and cyclic adenosine monophosphate [cAMP] responsive element binding protein [CREB]-1), sex hormone receptors (androgen, luteinizing- and follicle-stimulating hormone receptors [AR, LHR, and FSHR, respectively]), and antioxidant enzymes (glutathione S-transferase mu [GSTm]-5, glutathione peroxidase [GPx]-4, peroxiredoxin [PRx]-3), as well as histone deactylation (silent mating type information regulation 2 homolog 1, SIRT1) and growth-related (mammalian target of rapamycin complex 1, mTORC1) molecules were significantly altered in the AC group rat testes compared with those of the YC group. However, KRG-WE treatment of the AC group significantly (p < 0.05) attenuated these molecular changes. From these results, it can be concluded that long-term administration of KRG-WE significantly delayed the aging-induced testicular dysfunction.
URI
http://pubs.kist.re.kr/handle/201004/65477
ISSN
0531-5565
Appears in Collections:
KIST Publication > Article
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