Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering

Title
Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering
Authors
이현정Alec S.T.SmithHyok YooEun Hyun AhnJustin H. LeeGuozheng ShaoEkaterina NagornyakMichael A. LaflammeCharles E. MurryDeok-Ho Kim
Issue Date
2017-06
Publisher
Chemical communications
Citation
VOL 53-7415
Abstract
A lack of electrical conductivity and structural organization in currently available biomaterial scaffolds limits their utility for generating physiologically representative models of functional cardiac tissue. Here we report on the development of scalable, graphenefunctionalized topographies with anisotropic electrical conductivity for engineering the structural and functional phenotypes of macroscopic cardiac tissue constructs. Guided by anisotropic electroconductive and topographic cues, the tissue constructs displayed structural property enhancement in myofibrils and sarcomeres, and exhibited significant increases in the expression of cell– cell coupling and calcium handling proteins, as well as in action potential duration and peak calcium release.
URI
http://pubs.kist.re.kr/handle/201004/65874
ISSN
1359-7345
Appears in Collections:
KIST Publication > Article
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