p21-activated kinase 4 regulates HIF-1 alpha translation in cancer cells

Title
p21-activated kinase 4 regulates HIF-1 alpha translation in cancer cells
Authors
양은경김소연김현주더스틴 우
Issue Date
2017-04
Publisher
Biochemical and biophysical research communications
Citation
VOL 486, NO 2-276
Abstract
The p21-activated kinases (Paks) interact with Rac/Cdc42 GTPases to regulate the actin cytoskeleton as well as various signaling pathways. Although activation of Paks in many human cancers is known to mediate cancer progression, the role of Pak proteins in hypoxia is poorly understood. In this study, we found that both Pak1 and Pak4 are highly expressed in HeLa cervical cancer cells, but only Pak4 knockdown attenuates expression of hypoxia-inducible factor-1α (HIF-1α) in hypoxia. We further discovered that Pak4 regulates HIF-1α translation via the Akt-mTOR-4E-BP1 pathway under hypoxic conditions. These results support a novel connection between HIF-1α and Pak4 in hypoxic cancer cells, and provide insights into mechanisms whereby tumors respond to and thrive under oxygen-deficient conditions.
URI
http://pubs.kist.re.kr/handle/201004/65894
ISSN
0006-291X
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KIST Publication > Article
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