Polysaccharide-based Nanoparticles for Gene Delivery

Title
Polysaccharide-based Nanoparticles for Gene Delivery
Authors
권익찬김광명김선화허명숙이은정구희범이지영오근상손소희이소진
Keywords
Gene delivery; Nanomedicine; Nanoparticle; Nanotechnology; Polysaccharide; siRNA delivery
Issue Date
2017-04
Publisher
Topics in current chemistry
Citation
VOL 375, NO 2-31-19
Abstract
Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery.
URI
http://pubs.kist.re.kr/handle/201004/65925
ISSN
0340-1022
Appears in Collections:
KIST Publication > ETC
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