Polysaccharide-based Nanoparticles for Gene Delivery
- Polysaccharide-based Nanoparticles for Gene Delivery
- 권익찬; 김광명; 김선화; 허명숙; 이은정; 구희범; 이지영; 오근상; 손소희; 이소진
- Gene delivery; Nanomedicine; Nanoparticle; Nanotechnology; Polysaccharide; siRNA delivery
- Issue Date
- Topics in current chemistry
- VOL 375, NO 2-31-19
- Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery.
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