Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly

Title
Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly
Authors
성지혜김현빈Chae-Min YiJihyun YuNa-Rae LeeSang Won KimNoh-Jin LeeNam-Jung KimKyung-Soo InnJun Lee
Issue Date
2017-07
Publisher
Chemical communications
Citation
VOL 52-7047
Abstract
Despite the diverse pharmacological activities of berberine, including anti-cancer and anti-inflammatory effects, the direct proteomic targets of berberine have remained largely unknown. Here, we have identified actin as a direct proteomic target of berberine using an affinity-based chemical probe. In addition, we found that actin assembly was significantly modulated by berberine in vitro at the biochemical level and cellular level.
URI
http://pubs.kist.re.kr/handle/201004/66061
ISSN
1359-7345
Appears in Collections:
KIST Publication > Article
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