Genetically Engineered Phage Induced Selective H9c3 Cardiomyocytes Patterning in PDMS Microgrooves
- Genetically Engineered Phage Induced Selective H9c3 Cardiomyocytes Patterning in PDMS Microgrooves
- 전호정; 권청아; 김용준
- PDMS; micropatterns; RGD-phage; cell-surface interaction; cardiomyocytes
- Issue Date
- VOL 10, NO 8-973-8
- A micro-patterned cell adhesive surface was prepared for future design of medical devices. One-dimensional polydimethylsiloxane (PDMS) micro-patterns were prepared by a photolithography process. Afterwards, recombinant filamentous phages that displayed a short binding motif with a cell adhesive peptide (-RGD-) on p8 proteins were immobilized on PDMS microgrooves through simple contact printing to study the cellular response of rat H9c2 cardiomyocyte. While the cell density decreased on PDMS micro-patterns, we observed enhanced cell proliferation and cell to surface interaction on the RGD-phage coated PDMS microgrooves. The RGD-phage coating also supported a better alignment of cell spreading rather than isotropic cell growths as we observed on non-pattered PDMS surface.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.