Dioscin suppresses TGF-b1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration and invasion

Title
Dioscin suppresses TGF-b1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration and invasion
Authors
김영주Won-Chul LimHyunhee KimKyung-Chul ChoiIn Ho LeeKi Heon LeeMi Kyung KimHyeonseok Ko
Keywords
Dioscin; Invasion; Epithelial?mesenchymal transition (EMT); Transforming growth factor-beta 1 (TGF-β1); Lung cancer; Migration
Issue Date
2017-08
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 27, NO 15-3348
Abstract
Epithelial-to-mesenchymal transition (EMT), an important cellular process, occurs during cancer development and progression, has a crucial role in metastasis by enhancing the motility of tumor cells. Dioscin is a polyphenolic component isolated from Phyllanthus amarus, which exhibits a wide range of pharmacological and physiological activities, such as anti-tumor, anti-inflammatory, anti-obesity, antifungal, and anti-viral activities. However, the possible role of dioscin in the EMT is unclear. We investigated the suppressive effect of dioscin on the EMT. Transforming growth factor-beta 1 (TGF-beta 1) is known to induce EMT in a number of cancer cell types and promote lung adenocarcinoma migration and invasion. To verify the inhibitory role of dioscin in lung cancer migration and invasion, we investigated the use of dioscin as inhibitors of TGF-beta 1-induced EMT in A549 lung cancer cells in vitro. Here, we found that dioscin prominently increased expression of the epithelial marker E-cadherin and expression of the mesenchymal marker N-cadherin and Snail during the TGF-b1-induced EMT. In addition, dioscin inhibited the TGF-beta 1-induced increase in cell migration and invasion of A549 lung cancer cells. Also, dioscin remarkably inhibited TGF-beta 1-regulated activation of MMP-2/9, Smad2, and p38. Taken together, our findings provide new evidence that dioscin suppresses lung cancer migration, and invasion in vitro by inhibiting the TGF-beta 1-induced EMT.
URI
http://pubs.kist.re.kr/handle/201004/66174
ISSN
0960-894X
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KIST Publication > Article
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