Effect of processing method on platycodin D content in Platycodon grandiflorum roots
- Effect of processing method on platycodin D content in Platycodon grandiflorum roots
- 권재영; Hyaemin Lee; Nahyun Kim; Je-Hyun Lee; Mi Hee Woo; Jinwoong Kim; Yeong Shik Kim; Dongho Lee
- Platycodon grandiflorum; Platycodi Radix; Platycodin D; HPLC?ELSD; Processing method
- Issue Date
- Archives of pharmacal research
- VOL 40, NO 9-1093
- Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC-ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC-ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 A degrees C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.
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