Gordonic Acid, a Polyketide Glycoside Derived from Bacterial Coculture of Streptomyces and Gordonia Species

Title
Gordonic Acid, a Polyketide Glycoside Derived from Bacterial Coculture of Streptomyces and Gordonia Species
Authors
권학철박진수박현봉이승일신보라오동찬
Keywords
Bacterial Coculture; Streptomyces; Gordonia; Polyketide Glycoside; Gordonic acid; lipomycin derivative
Issue Date
2017-09
Publisher
Journal of natural products
Citation
VOL 80, NO 9-2546
Abstract
Despite numerous efforts to discover novel bioactive products from microorganisms, previously reported compounds are repetitively reisolated. A new polyketide glycoside, gordonic acid (1), isolated from the mixed culture of two Gram-positive bacteria, Gordonia sp. KMC005 and Streptomyces tendae KMC006, is reported. The structure of 1 was characterized as an acyclic polyene polyketide substituted with a,beta-D-digitoxopyranose through NMR, HR-ESI-QTOF-MS, IR, and UV spectral data. The stereochemistry for 1 was determined by Mosher's method followed by 2D NOESY analysis and by NMR chemical shift calculations supported by DP4 analysis. Gordonic acid (1) showed weak activity against Micrococcus luteus and Enterococcus hirae.
URI
http://pubs.kist.re.kr/handle/201004/66300
ISSN
0163-3864
Appears in Collections:
KIST Publication > Article
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