Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia

Title
Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia
Authors
양은경Seongyeol LeeJieon LeeSehyun ChaeYunwon MoonHo-Youl LeeBongju Park황대희박현성
Issue Date
2017-11
Publisher
Nucleic acids research
Citation
VOL 45, NO 20-11657
Abstract
Hypoxia increases both active and repressive histone methylation levels via decreased activity of histone demethylases. However, how such increases coordinately regulate induction or repression of hypoxia-responsive genes is largely unknown. Here, we profiled active and repressive histone tri-methylations (H3K4me3, H3K9me3, and H3K27me3) and analyzed gene expression profiles in human adipocyte-derived stem cells under hypoxia. We identified differentially expressed genes (DEGs) and differentially methylated genes (DMGs) by hypoxia and clustered the DEGs and DMGs into four major groups. We found that each group of DEGs was predominantly associated with alterations in only one type among the three histone tri-methylations. Moreover, the four groups of DEGs were associated with different TFs and localization patterns of their predominant types of H3K4me3, H3K9me3 and H3K27me3. Our results suggest that the association of altered gene expression with prominent single-type histone tri-methylations characterized by different localization patterns and with different sets of TFs contributes to regulation of particular sets of genes, which can serve as a model for coordinated epigenetic regulation of gene expression under hypoxia.
URI
http://pubs.kist.re.kr/handle/201004/66336
ISSN
0305-1048
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KIST Publication > Article
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