Comprehensive study on the roles of released ions from biodegradable Mg-5 wt% Ca-1 wt% Zn alloy in bone regeneration

Title
Comprehensive study on the roles of released ions from biodegradable Mg-5 wt% Ca-1 wt% Zn alloy in bone regeneration
Authors
석현광김유찬전호정한형섭김희경이강식이동호이지욱조성윤노형진
Keywords
Osteoblast; osteoclast; macrophages; biodegradable; magnesium; bone regeneration
Issue Date
2017-10
Publisher
Journal of tissue engineering and regenerative medicine.
Citation
VOL 11, NO 10-2724
Abstract
We report here the effect of micro-environmental changes from biodegradable magnesium alloys on the activities of cells – osteoblasts, osteoclasts and macrophages – which play critical roles in each phase of the bone-regeneration process. Despite positive bone formation effects from several in vivo studies, minimal progress has been made in identifying underlying mechanisms through in vitro studies, which are currently concentrated on osteoblastic activities. The observed in vitro and in vivo results indicated that alkaline pH and released magnesium and zinc ions derived from Mg– 5 wt% Ca– 1 wt% Zn alloy biodegradation promote the progress of bone formation. In contrast, alkaline pH and magnesium ions remarkably suppressed osteoclastic activities and pro-inflammatory cytokine production, closely related to osteolysis and prosthesis failure. Findings from the present study conclude that the degradation of Mg– 1 wt% Zn alloys can promote new bone formation by simultaneously affecting the complex combination of variable cellular activities and phases.
URI
http://pubs.kist.re.kr/handle/201004/66368
ISSN
1932-6254
Appears in Collections:
KIST Publication > Article
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