Image-based analysis of intracellular tau aggregation by using tau-BiFC cell model

Title
Image-based analysis of intracellular tau aggregation by using tau-BiFC cell model
Authors
김동진김윤경김도희임성수
Keywords
Tau protein; Tau aggregation; Tau-BiFC cells; Tau phosphorylation; Forskolin; Cell image analysis; High content imaging system (Operetta™); Harmony? software
Issue Date
2016-12
Publisher
Methods in Molecular Biology
Citation
VOL 1523-347
Abstract
Abnormal tau aggregation is a pathological hallmark of neurodegenerative disease classified as tauopathy. Preventing tau aggregation becomes an important therapeutic strategy to cure tau-mediated neurodegeneration. Here, we describe a method to investigate intracellular tau aggregation by using a recently developed tau aggregation cell-based model named tau-BiFC. High-throughput and high-contents screening method for quantifying intracellular tau aggregation would expedite the discovery of drugs that inhibit tau aggregation.
URI
http://pubs.kist.re.kr/handle/201004/66407
ISSN
1064-3745
Appears in Collections:
KIST Publication > ETC
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE