Image-based analysis of intracellular tau aggregation by using tau-BiFC cell model
- Image-based analysis of intracellular tau aggregation by using tau-BiFC cell model
- 김동진; 김윤경; 김도희; 임성수
- Tau protein; Tau aggregation; Tau-BiFC cells; Tau phosphorylation; Forskolin; Cell image analysis; High content imaging system (Operetta™); Harmony？ software
- Issue Date
- Methods in Molecular Biology
- VOL 1523-347
- Abnormal tau aggregation is a pathological hallmark of neurodegenerative disease classified as tauopathy. Preventing tau aggregation becomes an important therapeutic strategy to cure tau-mediated neurodegeneration. Here, we describe a method to investigate intracellular tau aggregation by using a recently developed tau aggregation cell-based model named tau-BiFC. High-throughput and high-contents screening method for quantifying intracellular tau aggregation would expedite the discovery of drugs that inhibit tau aggregation.
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- KIST Publication > ETC
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