Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat

Title
Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat
Authors
류재천조윤Jung-hee LimMi-Kyung SongSeung-Chan JeongKyuhong LeeYongju HeoTae Sung Kim
Keywords
indoor air pollutant; aldehyde; hexanal; respiratory system; environmental genomics
Issue Date
2017-02
Publisher
Environmental toxicology
Citation
VOL 32, NO 2-396
Abstract
Hexanal is a major component of indoor air pollutants and is a kind of aldehydes; it has adverse effects on human health. We performed an in vivo inhalation study and transcriptomic analysis to determine the mode of toxic actions in response to hexanal. Fischer 344 rats of both sexes were exposed by inhalation to hexanal aerosol for 4 hday(-1), 5 daysweek(-1) for 4 weeks at 0, 600, 1000, and 1500 ppm. Throughout our microarray-based genome-wide expression analysis, we identified 56 differentially expressed genes in three doses of hexanal; among these genes, 11 genes showed dose-dependent expression patterns (10 downregulated and 1 upregulated, 1.5-fold, p<0.05). Through a comparative toxicogenomics database (CTD) analysis of 11 genes, we determined that five genes (CCL12, DDIT4, KLF2, CEBPD, and ADH6) are linked to diverse disease categories such as cancer, respiratory tract disease, and immune system disease. These diseases were previously known for being induced by volatile organic compounds (VOCs). Our data demonstrated that the hexanal-induced dose-dependent altered genes could be valuable quantitative biomarkers to predict hexanal exposure and to perform relative risk assessments, including pulmonary toxicity.
URI
http://pubs.kist.re.kr/handle/201004/66446
ISSN
1520-4081
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE