Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth

Title
Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth
Authors
김수남고가연이상진조아영이재철서동완강종순김시관김용기배규운
Keywords
ginsenoside Rg1; myotube hypertrophy; myoblast differentiation; promyogenic signaling; myogenic conversion
Issue Date
2017-10
Publisher
Journal of Ginseng Research
Citation
VOL 41, NO 4-614
Abstract
Background: Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth. Methods: C2C12 myoblasts, MyoD-transfected 10T1/2 embryonic fibroblasts, and HEK293T cells were treated with Rg1 and differentiated for 2 d, subjected to immunoblotting, immunocytochemistry, or immunoprecipitation. Results: Rg1 activated promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promote the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation. Through the activation of Akt/mammalian target of rapamycin pathway, Rg1 induced myotube growth and prevented dexamethasone-induced myotube atrophy. Furthermore, Rg1 increased MyoD-dependent myogenic conversion of fibroblast. Conclusion: Rg1 upregulates promyogenic kinases, especially Akt, resulting in improvement of myoblast differentiation and myotube growth.
URI
http://pubs.kist.re.kr/handle/201004/66459
ISSN
1226-8453
Appears in Collections:
KIST Publication > Article
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