Full metadata record

DC FieldValueLanguage
dc.contributor.author김수남-
dc.contributor.author최용수-
dc.contributor.author김진철-
dc.contributor.author이설림-
dc.contributor.author정유정-
dc.contributor.author강기성-
dc.contributor.author김용기-
dc.date.accessioned2021-06-09T04:18:46Z-
dc.date.available2021-06-09T04:18:46Z-
dc.date.issued2017-11-
dc.identifier.citationVOL 493, NO 1-226-
dc.identifier.issn0006-291X-
dc.identifier.other49649-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/66460-
dc.description.abstractEupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) is a flavonoid compound exhibiting several beneficial biological activities, including neuroprotection, anti-cancer, antinociception, chondroprotection, anti oxidation, and anti-inflammation. Our previous study demonstrated that eupatilin specifically activates peroxisome proliferator-activated receptor alpha (PPAR alpha) through direct binding. The PPAR subfamily includes ligand-dependent transcription factors that consist of three isotypes: PPAR alpha, PPAR beta/delta, and PPAR gamma. All isotypes are involved in inflammation, epidermal proliferation/differentiation and skin barrier function. Among them, PPAR alpha regulates lipid and glucose metabolism and skin homeostasis. In this study, we confirm that the ability of eupatilin as a PPAR alpha activator significantly inhibited tumor necrosis factor-alpha (TNF alpha)-induced matrix metalloproteinase (MMP)-2/-9 expression and proteolytic activity in HaCaT human epidermal keratinocytes. Furthermore, we found that eupatilin subsequently suppressed I kappa B alpha phosphorylation, blocked NF-kappa B p65 nuclear translocation and down-regulated MAPK/AP-1 signaling via PPAR alpha activation. Taken together, our data suggest that eupatilin inhibits TNF alpha-induced MMP-2/-9 expression by suppressing NF-kappa B and MAPK/AP-1 pathways via PPAR alpha. Our findings suggest the usefulness of eupatilin for preventing skin aging.-
dc.publisherBiochemical and biophysical research communications-
dc.subjecteupatilin-
dc.subjectNFkB-
dc.subjectPPARa-
dc.subjectAP-1-
dc.subjectMMPs-
dc.titleEupatilin with PPAR alpha agonistic effects inhibits TNF alpha-induced MMP signaling in HaCaT cells-
dc.typeArticle-
dc.relation.page220226-
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE