Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin

Title
Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin
Authors
엄병헌김수남김진철이설림이다혜성상현정낙신김용기
Keywords
Cirsium setidens; Pectolinarigenin; Melanogenesis; Pectolinarin; Microwave; Whitening
Issue Date
2017-11
Publisher
Biochemical and biophysical research communications
Citation
VOL 493, NO 1-772
Abstract
Pectolinarin and pectolinarigenin have been reported to be major compounds in Cirsium setidens. In the present study, we demonstrated inhibitory effects of pectolinarin and pectolinarigenin from C. setidens on melanogenesis. Melanin synthesis was decreased in both pectolinarin- and pectolinarigenin-treated melan-a cells and in a reconstructed human skin model. However, pectolinarigenin treatment showed more potent inhibitory activity of melanin synthesis than did pectolinarin treatment. The concentrations of pectolinarin and pectolinarigenin in C setidens water extracts were determined by HPLC. Unfortunately, the amount of pectolinarigenin of C setidens water extract was lower than that of pectolinarin. To increase the pectolinarigenin content in C setidens water extract, several component conversion methods were studied. Consequently, we identified that microwave irradiation under 1% acetic acid was an optimum sugar elimination method.
URI
http://pubs.kist.re.kr/handle/201004/66461
ISSN
0006-291X
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KIST Publication > Article
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