Molecular dynamics simulation of cytotoxicity of graphene nanosheets to blood-coagulation protein

Title
Molecular dynamics simulation of cytotoxicity of graphene nanosheets to blood-coagulation protein
Authors
옥명렬조병철윤현정우상욱
Keywords
molecular dynamics; biophysics; blood protein; graphene
Issue Date
2017-03
Publisher
Biointerphases
Citation
VOL 12, NO 1-01A403-8
Abstract
Graphene is a nanomaterial that is widely used in electronics, biomedicine, and drug-delivery systems. Although it has many industrial applications, the cytotoxicity of graphene has not been sufficiently studied. In this study, the authors used molecular dynamics simulation to investigate how a graphene nanosheet affects a blood-coagulation protein, namely, a tissue factor/FVIIa binary complex bound to a lipid bilayer membrane, in a 4: 1 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2oleoyl-sn-glycero-3-phospho-l-serine lipid bilayer mixture. Based on the results, the authors suggest a mechanism for the cytotoxicity of graphene nanosheets to blood-coagulation protein at the molecular level.
URI
http://pubs.kist.re.kr/handle/201004/66467
ISSN
1559-4106
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE