Molecular dynamics simulation of cytotoxicity of graphene nanosheets to blood-coagulation protein
- Molecular dynamics simulation of cytotoxicity of graphene nanosheets to blood-coagulation protein
- 옥명렬; 조병철; 윤현정; 우상욱
- molecular dynamics; biophysics; blood protein; graphene
- Issue Date
- VOL 12, NO 1-01A403-8
- Graphene is a nanomaterial that is widely used in electronics, biomedicine, and drug-delivery systems. Although it has many industrial applications, the cytotoxicity of graphene has not been sufficiently studied. In this study, the authors used molecular dynamics simulation to investigate how a graphene nanosheet affects a blood-coagulation protein, namely, a tissue factor/FVIIa binary complex bound to a lipid bilayer membrane, in a 4: 1 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2oleoyl-sn-glycero-3-phospho-l-serine lipid bilayer mixture. Based on the results, the authors suggest a mechanism for the cytotoxicity of graphene nanosheets to blood-coagulation protein at the molecular level.
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- KIST Publication > Article
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