A new canthinone-type alkaloid isolated from Ailanthus altissima Swingle
- A new canthinone-type alkaloid isolated from Ailanthus altissima Swingle
- 권재영; Hye Mi Kim; Jin Su Lee; Jurdas Sezirahiga; Miran Jeong; Dongho Lee; Jung-Hye Choi; Dae Sik Jang
- Issue Date
- VOL 21, NO 5-642-10
- The present investigation of the chemical constituents of the stem barks of Ailanthus altissima has resulted in the isolation of six canthinone-type alkaloids, including a new compound, (R)-5-(1-hydroxyethyl)-canthine-6-one (1), and five known compounds (2-6). Moreover, four phenyl propanoids (7-10), two lignans (11 and 12), two triterpenoids (13 and 14) and a fatty acid (15) having previously known chemical structures were isolated during the same course of this study. The structure of the new compound was elucidated by physical (m.p., [alpha](D)) and spectroscopic data (H-1-NMR, C-13-NMR, 2D NMR, and HR-DART-MS) interpretation and its absolute configuration was determined by electronic circular dichroism (ECD) data and quantum chemical calculations. The inflammatory activities of the isolates were screened on lipopolysaccharide (LPS)-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells. Among these isolated compounds, six compounds exhibited significant inhibition of NO production, with IC50 values in the range of 5.92 +/- 0.9 to 15.09 +/- 1.8 mu M.
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