Facile synthesis of 4 "-O-alkyl-(-)- EGCG derivatives through regioselective deacetylative alkylation

Title
Facile synthesis of 4 "-O-alkyl-(-)- EGCG derivatives through regioselective deacetylative alkylation
Authors
추현아서유진김미경정유훈
Keywords
(?)-EGCG; deacetylative alkylation; regioselectivity
Issue Date
2017-04
Publisher
Synthetic communications
Citation
VOL 47, NO 7-659
Abstract
Therapeutic potential of the D-ring methyl ethers of (– )-epigallocatechin-3-gallate [(– )-EGCG] warrants extensive structure– activity relationship study of various D-ring ethers of (– )-EGCG but, for this purpose, efficient synthetic strategy needs to be developed. In this study, efficient preparation of the 4″-O-alkyl-(– )-EGCGs (4a– e) was demonstrated using KI/K2CO3-promoted deacetylative alkylation of peracetyl (– )-EGCG, which could be broadly utilized for the preparation of various D-ring alkyl ethers of (– )-EGCG and thereby extensive structure– activity relationship study.
URI
http://pubs.kist.re.kr/handle/201004/66499
ISSN
1532-2432
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KIST Publication > Article
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