Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARdelta and Adiponectin in ApoE KO Mice

Title
Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARdelta and Adiponectin in ApoE KO Mice
Authors
진창배김형자Yong-Jik LeeYoo-Na JangYoon-Mi HanHyun-Min KimJong-Min JeongMin Jeoung SonHong Seog Seo
Keywords
Aster glehni; Nonalcoholic fatty liver disease; Caffeoylquinic Acid-Rich Extract; ApoE KO Mice
Issue Date
2017-10
Publisher
PPAR Research
Citation
VOL 2017-19
Abstract
Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue. Body and abdominal adipose tissue weights and serum triglyceride level decreased in all groups treated with A. glehni. Serum adiponectin concentration and protein levels of peroxisome proliferator-activated receptor 𝛿 , 5󸀠 adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, superoxide dismutase, and PPAR𝛾 coactivator 1-alpha in liver tissues increased in the groups treated with A. glehni. Conversely, protein levels of ATP citrate lyase, fatty acid synthase, tumor necrosis factor 𝛼 , and 3-hydroxy-3-methylglutaryl-CoA reductase and the concentrations of interleukin 6 and reactive oxygen species decreased upon A. glehni. Triglyceride concentration in the liver was lower in mice treated with A. glehni than in control mice. Lipid accumulation in HepG2 and 3T3-L1 cells decreased upon A. glehni treatment; this effect was suppressed in the presence of the PPAR𝛿 antagonist,GSK0660.Our findings suggest that A. glehni extracts may ameliorate NAFLD through regulation of PPAR𝛿 , adiponectin, and the related subgenes.
URI
http://pubs.kist.re.kr/handle/201004/66551
ISSN
1687-4757
Appears in Collections:
KIST Publication > Article
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