Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease
- Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease
- 배애님; 박기덕; 박종현; 김태훈; 양하연; 박병건; 정서윤; 민선준; 태진성; 양혜진; 조승목; 조성진; 송현동; 묵인희; 이지연
- Alzheimer's disease; TSPO; inhibitors; Translocator protein; Mitochondrial permeability transition pore; Mitochondrial dysfunction
- Issue Date
- European journal of medicinal chemistry
- VOL 125-1192
- In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from A beta-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD.
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