Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

Title
Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease
Authors
배애님박기덕박종현김태훈양하연박병건정서윤민선준태진성양혜진조승목조성진송현동묵인희이지연
Keywords
Alzheimer's disease; TSPO; inhibitors; Translocator protein; Mitochondrial permeability transition pore; Mitochondrial dysfunction
Issue Date
2017-01
Publisher
European journal of medicinal chemistry
Citation
VOL 125-1192
Abstract
In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from A beta-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD.
URI
http://pubs.kist.re.kr/handle/201004/66564
ISSN
0223-5234
Appears in Collections:
KIST Publication > Article
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