Antidiabetic effect of SN158 through PPAR alpha/gamma dual activation in ob/ob mice

Title
Antidiabetic effect of SN158 through PPAR alpha/gamma dual activation in ob/ob mice
Authors
김수남정유정Yongkai CaoSuresh Paudel윤구천승훈배규운Li Tai Jin김용기
Keywords
SN158; PPAR; Insulin sensitivity
Issue Date
2017-04
Publisher
Chemico-biological interactions
Citation
VOL 268-30
Abstract
In this study, we aimed to demonstrate the antidiabetic potential of (E)-N-(4-(3-(5-bromo-4-hydroxy-2-methoxyphenyl)acryloyl) phenyl)-4-tert-butylbenzamide (SN158) through peroxisome proliferator-activated receptor (PPAR)-α/γ dual activation. SN158 interacted with both PPARα and PPARγ, and increased their transcriptional activities. Simultaneously, SN158 treatment led to an increase in adipogenic differentiation of 3T3-L1 preadipocytes and fatty acid oxidation in hepatocytes. In addition, glucose uptake in myotubes was significantly increased by SN158 treatment. Finally, SN158 significantly lowered the plasma levels of glucose, triglycerides, and free fatty acids in ob/ob mice without severe weight gain and hepatomegaly. These results suggest that SN158 can be useful as a potential therapeutic agent against type 2 diabetes and related metabolic disorders by alleviating glucose and lipid abnormalities.
URI
http://pubs.kist.re.kr/handle/201004/66664
ISSN
0009-2797
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE