Multivalent Aptamer-RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug-Resistant Cells

Title
Multivalent Aptamer-RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug-Resistant Cells
Authors
김선화정효석이수현황연주유현동정희선목혜정
Keywords
combination therapy; doxorubicin; multidrug-resistant cancer cells; multivalent aptamers; siRNA
Issue Date
2017-04
Publisher
Macromolecular bioscience
Citation
VOL 17, NO 4-1600343-6
Abstract
Multivalent aptamer-siRNA conjugates containing multiple mucin-1 aptamers and BCL2specific siRNA are synthesized, and doxorubicin, an anthracycline anticancer drug, is loaded into these conjugates through intercalation with nucleic acids. These doxorubicin-incorporated multivalent aptamer-siRNA conjugates are transfected to mucin-1 overexpressing MCF-7 breast cancer cells and their multidrug-resistant cell lines. Doxorubicin-incorporated multivalent aptamer-siRNA conjugates exert promising anticancer effects, such as activation of caspase-3/7 and decrease of cell viability, on multidrug-resistant cancer cells because of their high intracellular uptake efficiency. Thus, this delivery system is an efficient tool for combination oncotherapy with chemotherapeutics and nucleic acid drugs to overcome multidrug resistance.
URI
http://pubs.kist.re.kr/handle/201004/66691
ISSN
1616-5187
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KIST Publication > Article
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