Low-Level Environmental Cadmium Exposure Induces Kidney Tubule Damage in the General Population of Korean Adults
- Low-Level Environmental Cadmium Exposure Induces Kidney Tubule Damage in the General Population of Korean Adults
- 박경수; Sang-Yong Eom; Mi-Na Seo; Young-Sub Lee; Young-Seoub Hong; Seok-Joon Sohn; Yong-Dae Kim; Byung-Sun Choi; Ji-Ae Lim; Ho-Jang Kwon; Heon Kim; Jung-Duck Park
- Issue Date
- Archives of environmental contamination and toxicology
- VOL 73, NO 3-409
- Cadmium (Cd) is the most potent nephrotoxic heavy metal and may affect bone; it also has a long biological half-life in the human body. This study was designed to assess the effect of environmental low-level Cd exposure on kidney function and bone in the general population. The subjects of this cross-sectional study were 1907 healthy Korean adults who had not been exposed to Cd occupationally. We analyzed the concentrations of Cd in the urine, markers of renal tubule damage, such as beta(2)-microglobulin (beta(2)-MG) and N-acetyl-beta-D-glucosaminidase (NAG) activity in the urine, calculated the estimated glomerular filtration rate (eGFR) using serum creatinine, and measured bone mineral density (BMD). Also, we analyzed malondialdehyde (MDA) levels in the urine. The geometric mean concentration of Cd in urine was higher in women (1.36 mu g/g creatinine) than in men (0.82 mu g/g creatinine). Urinary Cd was significantly positively correlated with urinary beta(2)-MG and NAG activity, whereas it was negatively correlated with eGFR and BMD. The risk of renal tubule damage was significantly associated with urine Cd level, and the association remained significant after controlling for various confounding variables. However, no association was observed between urinary Cd level and glomerular dysfunction or bone damage. The concentration of MDA was increased with urinary Cd level in a dose-dependent manner. These findings suggest that low-level environmental Cd exposure may cause microscopic damage to renal tubules through oxidative stress but might not impair kidney glomeruli or bones.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.