New role of human ribosomal protein S3: Regulation of cell cycle via phosphorylation by cyclin-dependent kinase 2

Title
New role of human ribosomal protein S3: Regulation of cell cycle via phosphorylation by cyclin-dependent kinase 2
Authors
김기선Se Hee HanJi Hyung ChunJoon KimYe Sun Han
Keywords
human ribosomal protein S3; cyclin?dependent kinase 2; cell cycle regulation; in vitro kinase assay; protein?protein interaction
Issue Date
2017-05
Publisher
Oncology Letters
Citation
VOL 13, NO 5-3687
Abstract
Human ribosomal protein S3 (hRpS3) is a component of the 40S ribosomal subunit that associated in protein synthesis. hRpS3 has additional ribosomal functions such as DNA repair, transcription, metastasis, and apoptosis via interaction with numerous signaling molecules and has different modifications. Cyclin-dependent kinases (CDKs) are heterodimeric serine/threonine protein kinases that regulate cell cycle progression. Among its members, the Cdkl-cyclin B complex is known to control cell progression in the G2/M phase, while Cdk2-cyclin EA complexes function in GUS and S/G2 transition. In our previous study, we observed interaction between hRpS3 and Cdkl. The present study investigated the interaction between hRpS3 and Cdk2. Cdk2 phosphorylated hRps3 at amino acid residues S6 and T221 during the S-phase. Furthermore, hRpS3 knockdown delayed cell cycle progression by modulating the expression of cell cycle-related proteins, including cyclin B1 and cyclin El. These findings suggest that hRpS3 is involved in Cdk2-mediated cell cycle regulation.
URI
http://pubs.kist.re.kr/handle/201004/66736
ISSN
1792-1074
Appears in Collections:
KIST Publication > Article
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