The effect of solvents and hydrophilic additive on stable coating and controllable sirolimus release system for drug-eluting stent

Title
The effect of solvents and hydrophilic additive on stable coating and controllable sirolimus release system for drug-eluting stent
Authors
한동근김만호정윤기김성민박성빈타렉박방주
Keywords
Drug-eluting stent; Biodegradable polymer; Sirolimus; Ultrasonic coating; Drug release
Issue Date
2017-09
Publisher
Materials science and engineering C : materials for biological applications
Citation
VOL 78-46
Abstract
Various drug-eluting stents (DESs) have been developed to prevent restenosis after stent implantation. However, DES still needs to improve the drug-in-polymer coating stability and control of drug release for effective clinical treatment. In this study, the cobalt-chromium (Co-Cr) alloy surface was coated with biodegradable poly(D,L-lactide) (PDLLA) and sirolimus (SRL) mixed with hydrophilic Pluronic F127 additive by using ultrasonic spray coating system in order to achieve a stable coating surface and control SRL release. The degradation of PDLLA/SRL coating was studied under physiological solution. It was found that adding F127 reduced the degradation of PDLLA and improved the coating stability during 60 days. The effects of organic solvent such as chloroform and tetrahydrofuran (THF) on the coating uniformity were also examined. It was revealed that THF produced a very smooth and uniform coating compared to chloroform. The patterns of in vitro drug release according to the type of organic solvent and hydrophilic additive proposed the possibility of controllable drug release design in DES. It was found that using F127 the drug release was sustained regardless of the organic solvent used. In addition, THF was able to get faster and controlled release profile when compared to chloroform. The structure of SRL molecules in different organic solvents was investigated using ultra-small angle neutron scattering. Furthermore, the structure of SRL is concentration-dependent in chloroform with tight nature under high concentration, but concentration-independent in THE These results strongly demonstrated that coating stability and drug release patterns can be changed by physicochemical properties of various parameters such as organic solvents, additive, and coating strategy.
URI
http://pubs.kist.re.kr/handle/201004/66861
ISSN
0928-4931
Appears in Collections:
KIST Publication > Article
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