Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus

Title
Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus
Authors
김정진류이치 나카지마김영수신안나정민주박아형정용철조선미양승경박호성조성환심인섭정재훈백세범조지 어거스틴김대수
Issue Date
2017-08
Publisher
Neuron
Citation
VOL 95, NO 5-1196
Abstract
Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that optogenetic photostimulation of inhibitory BG inputs from the globus pallidus induces a surge of action potentials in the ventrolateral thalamic (VL) neurons and muscle contractions during the post-inhibitory period. Reduction of the neuronal population with this post-inhibitory rebound firing by knockout of T-type Ca2+ channels or photoinhibition abolishes multiple motor responses induced by the inhibitory BG input. In a low dopamine state, the number of VL neurons showing post-inhibitory firing increases, while reducing the number of active VL neurons via photoinhibition of BG input, effectively prevents Parkinson disease (PD)-like motor symptoms. Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities.
URI
http://pubs.kist.re.kr/handle/201004/66887
ISSN
0896-6273
Appears in Collections:
KIST Publication > Article
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