Surface functionalized magnetic nanoparticles shift cell behavior with on/off magnetic fields

Title
Surface functionalized magnetic nanoparticles shift cell behavior with on/off magnetic fields
Authors
박귀덕전성범라메쉬Taufik Bonaedy반세영윤규식
Keywords
atomic force microscopy; cell stiffness; cytotoxicity; interface; magentic nanoparticles
Issue Date
2018-02
Publisher
Journal of cellular physiology
Citation
VOL 233, NO 2-1178
Abstract
Magnetic nanoparticles (MNPs) are used as contrast agents and targeted drug delivery systems (TDDS) due to their favorable size, surface charge, and magnetic properties. Unfortunately, the toxicity associated with MNPs limits their biological applications. Surface functionalization of MNPs with selective polymers alters the surface chemistry to impart better biocompatibility. We report the preparation of surface functionalized MNPs using iron oxide NPs (MNPs), poly (lactic-co-glycolic acid) (PLGA), and sodium alginate via co-precipitation, emulsification, and electro-spraying, respectively. The NPs are in the nanosize range and negatively charged. Morphological and structural analyses affirm the surface functionalized nanostructure of the NPs. The surface functionalized MNPs are biocompatible, and demonstrate enhanced intracellular delivery under an applied magnetic field (H), which evinces the targeting ability of MNPs. After NP treatment, the physico-mechanical properties of fibroblasts are decided by the selective MNP uptake under on or off magnetic field conditions. We envision potential use of biocompatible surface functionalized MNP for intracellular-, targeted-DDS, imaging, and for investigating cellular mechanics.
URI
http://pubs.kist.re.kr/handle/201004/66889
ISSN
0021-9541
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KIST Publication > Article
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