Near-infrared fluorescent probes for detection of glutathione and their applications in fluorescent imaging in living cells and tumor-bearing mouse
- Near-infrared fluorescent probes for detection of glutathione and their applications in fluorescent imaging in living cells and tumor-bearing mouse
- 김세훈; 정근수; 김가영; 이다영; Xiao Luo; 양유준; Xiaoqiang Chen; 윤주영
- Issue Date
- Journal of materials chemistry. B, Materials for biology and medicine
- VOL 6, NO 17-2546
- Two new cyanine-based fluorescent probes 1 and 2 have been developed. Probe 1 bears two cyanine units in a single molecule, and probe 2 contains a bis(trifluoromethyl)benzenethiol moiety. Both are non-fluorescent. The addition of intracellular glutathione (GSH) significantly enhanced the NIR fluorescence of the two probes. Both probes were used to image varying amounts of GSH in living cells. In tumor bearing mice, the in vivo fluorescence intensity of both probes was higher in tumors, where GSH is overexpressed, than in normal tissues. These results suggest that these new fluorogenic probes have potential for GSH-targeting diagnostic imaging.
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