Near-infrared fluorescent probes for detection of glutathione and their applications in fluorescent imaging in living cells and tumor-bearing mouse

Title
Near-infrared fluorescent probes for detection of glutathione and their applications in fluorescent imaging in living cells and tumor-bearing mouse
Authors
김세훈정근수김가영이다영Xiao Luo양유준Xiaoqiang Chen윤주영
Issue Date
2018-05
Publisher
Journal of materials chemistry. B, Materials for biology and medicine
Citation
VOL 6, NO 17-2546
Abstract
Two new cyanine-based fluorescent probes 1 and 2 have been developed. Probe 1 bears two cyanine units in a single molecule, and probe 2 contains a bis(trifluoromethyl)benzenethiol moiety. Both are non-fluorescent. The addition of intracellular glutathione (GSH) significantly enhanced the NIR fluorescence of the two probes. Both probes were used to image varying amounts of GSH in living cells. In tumor bearing mice, the in vivo fluorescence intensity of both probes was higher in tumors, where GSH is overexpressed, than in normal tissues. These results suggest that these new fluorogenic probes have potential for GSH-targeting diagnostic imaging.
URI
http://pubs.kist.re.kr/handle/201004/66983
ISSN
2050-750X
Appears in Collections:
KIST Publication > Article
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