Recent advances in biocompatible semiconductor nanocrystals for immunobiological applications
- Recent advances in biocompatible semiconductor nanocrystals for immunobiological applications
- 김광명; Sitansu Sekhar Nanda; 김민직; Georgia C. Papaefthymiou; Subramanian Tamil Selvan; 이동기
- Quantum dots; Immunoassay; Immunosensor; Immunofluorescent imaging; Immunotherapy
- Issue Date
- Colloids and surfaces. B, Biointerfaces
- VOL 159-654
- Quantum confinement in inorganic semiconductor nanocrystals produces brightly luminescent nanoparticles endowed with unique photo-physical properties, such as tunable optical properties. These have found widespread applications in nanotechnology. The ability to render such nanostructures biocompatible, while maintaining their tunable radiation in the visible range of the electromagnetic spectrum, renders them appropriate for bio-applications. Promising in vitro and in vivo diagnostic applications have been demonstrated, such as fluorescence-based detection of biological interactions, single molecule tracking, multiplexing and immunoassaying. In particular, these fluorescent inorganic semiconductor nanocrystals, generally known as quantum dots, have the potential of remarkable immunobiological applications. This review focuses on the current status of biocompatible quantum dots and their applications in immunobiology − immunosensing, immunofluorescent imaging and immunotherapy.
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