Deep tissue penetration of nanoparticles using pulsed-high intensity focused ultrasound

Title
Deep tissue penetration of nanoparticles using pulsed-high intensity focused ultrasound
Authors
권익찬김광명윤홍열전상민엄우람유동길손세진박재형
Keywords
Pulsed-high intensity focused ultrasound; Tissue penetration; Nanoparticle; Drug delivery
Issue Date
2017-11
Publisher
Nano Convergence
Citation
VOL 4, NO 30-10
Abstract
Recently, ultrasound (US)-based drug delivery strategies have received attention to improve enhanced permeation and retention (EPR) effect-based passive targeting efficiency of nanoparticles in vitro and in vivo conditions. Among the US treatment techniques, pulsed-high intensity focused ultrasound (pHIFU) have specialized for improving tissue penetration of various macromolecules and nanoparticles without irreversible tissue damages. In this study, we have demonstrated that pHIFU could be utilized to improve tissue penetration of fluorescent dye-labeled glycol chitosan nanoparticles (FCNPs) in femoral tissue of mice. pHIFU could improve blood flow of the targeted-blood vessel in femoral tissue. In addition, tissue penetration of FCNPs was specifically increased 5.7-, 8- and 9.3-folds than that of non-treated (0 W pHIFU) femoral tissue, when the femoral tissue was treated with 10, 20 and 50 W of pHIFU, respectively. However, tissue penetration of FCNPs was significantly reduced after 3 h post-pHIFU treatment (50 W). Because overdose (50 W) of pHIFU led to irreversible tissue damages, including the edema and chapped red blood cells. These overall results support that pHIFU treatment can enhance the extravasation and tissue penetration of FCNPs as well as induce irreversible tissue damages. We expect that our results can provide advantages to optimize pHIFU-mediated delivery strategy of nanoparticles for further clinical applications.
URI
http://pubs.kist.re.kr/handle/201004/67005
ISSN
2196-5404
Appears in Collections:
KIST Publication > Article
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