In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering

Title
In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering
Authors
김광명윤홍열한상수이지영조명옥심혜은정지은이동은김환욱이존환허강무강선웅
Issue Date
2018-01
Publisher
Polymer Chemistry
Citation
VOL 9, NO 1-27
Abstract
We report a biocompatible and in situ cross-linkable hydrogel derived from hyaluronic acid via a bioorthogonal reaction and confirm the clinical potential of our hydrogel through in vivo cartilage regeneration. Gelation is attributed to copper-free click reactions between an azide and dibenzyl cyclooctyne. HA-PEG4-DBCO was synthesized and cross-linked via 4-arm PEG azide. The effects of the ratio of HA-PEG4-DBCO to 4-arm PEG azide on the gelation time, microstructure, surface morphology, equilibrium swelling, and compressive modulus were examined. The potential of a hydrogel as an injectable scaffold was demonstrated by the encapsulation of chondrocytes within the hydrogel matrix in vitro and in vivo. The results demonstrated that the hydrogel supported cell survival, and the cells regenerated cartilaginous tissue. In addition, these characteristics provide potential opportunities for the use of injectable hydrogels in tissue engineering applications.
URI
http://pubs.kist.re.kr/handle/201004/67033
ISSN
1759-9954
Appears in Collections:
KIST Publication > Article
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