Nanoneedle Transistor-Based Sensors for the Selective Detection of Intracellular Calcium Ions

Title
Nanoneedle Transistor-Based Sensors for the Selective Detection of Intracellular Calcium Ions
Authors
손동희박성영김병주고준태김태현안상민장도영김규태제원호홍승훈
Keywords
carbon nanotube; real-time sensor; field effect transistor; Fluo-4-AM dye; intracellular calcium ion; nanoneedle transistor-based sensor
Issue Date
2011-05
Publisher
ACS Nano
Citation
VOL 5, NO 5-3895
Abstract
We developed a nanoneedle transistor-based sensor (NTS) for the selective detection of calcium ions inside a living cell. In this work, a single-walled carbon nanotube-based field effect transistor (swCNT-FET) was first fabricated at the end of a glass nanopipette and functionalized with Fluo-4-AM probe dye. The selective binding of calcium Ions onto the dye molecules altered the charge state of the dye molecules, resulting in the change of the source-drain current of the swCNT-FET as well as the fluorescence intensity from the dye. We demonstrated the electrical and fluorescence detection of the concentration change of intracellular calcium ions inside a HeLa cell using the NTS.
URI
http://pubs.kist.re.kr/handle/201004/67052
ISSN
1936-0851
Appears in Collections:
KIST Publication > Article
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