Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases

Title
Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases
Authors
손동희이종하이동준가파리 루즈벳유수민김석주이지은조혜림윤선호양시수안이승현키아오 슈타오릉대순신상훈송준걸김재민김태호이학용김종훈소민이노현황철성남상욱루난슈현택환최승홍김대형
Issue Date
2015-06
Publisher
ACS Nano
Citation
VOL 9, NO 6-5946
Abstract
Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.
URI
http://pubs.kist.re.kr/handle/201004/67058
ISSN
1936-0851
Appears in Collections:
KIST Publication > Article
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