Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases
- Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases
- 손동희; 이종하; 이동준; 가파리 루즈벳; 유수민; 김석주; 이지은; 조혜림; 윤선호; 양시수안; 이승현; 키아오 슈타오; 릉대순; 신상훈; 송준걸; 김재민; 김태호; 이학용; 김종훈; 소민; 이노현; 황철성; 남상욱; 루난슈; 현택환; 최승홍; 김대형
- Issue Date
- ACS Nano
- VOL 9, NO 6-5946
- Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.
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