Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
- Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
- 임혜원; 황홍익; 송승주; Yong Ryoul Yang; Jung Hoon Jung; Su-Jeong Kim; Sora Yoon; Jin-Hoe Hur; Jae-Il Park; Cheol Lee; Dougu Nam; Young-Kyo Seo; Joung-Hun Kim; Pann-Ghill Suh
- Long-term potentiation; Spatial memory; O-GlcNAcylation
- Issue Date
- Scientific Reports
- VOL 7, NO 44921-9
- O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga(+/-)mice which have an increased level of O-GlcNAcylation, and found that Oga(+/-)mice exhibited impaired spatial learning and memory. Consistent with this result, Oga(+/-)mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-OGlcNAcylation in learning and memory.
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