Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

Title
Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
Authors
임혜원황홍익송승주Yong Ryoul YangJung Hoon JungSu-Jeong KimSora YoonJin-Hoe HurJae-Il ParkCheol LeeDougu NamYoung-Kyo SeoJoung-Hun KimPann-Ghill Suh
Keywords
Long-term potentiation; Spatial memory; O-GlcNAcylation
Issue Date
2017-04
Publisher
Scientific Reports
Citation
VOL 7, NO 44921-9
Abstract
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga(+/-)mice which have an increased level of O-GlcNAcylation, and found that Oga(+/-)mice exhibited impaired spatial learning and memory. Consistent with this result, Oga(+/-)mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-OGlcNAcylation in learning and memory.
URI
http://pubs.kist.re.kr/handle/201004/67113
ISSN
2045-2322
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KIST Publication > Article
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