Catalytic Asymmetric Synthesis of Secondary Nitriles via Stereoconvergent Negishi Arylations and Alkenylations of Racemic α-Bromonitriles

Title
Catalytic Asymmetric Synthesis of Secondary Nitriles via Stereoconvergent Negishi Arylations and Alkenylations of Racemic α-Bromonitriles
Authors
최준원Gregory C. Fu
Issue Date
2012-05
Publisher
Journal of the American Chemical Society
Citation
VOL 134, NO 22-9105
Abstract
The first method for the stereoconvergent cross-coupling of racemic alpha-halonitriles is described, specifically, nickel-catalyzed Negishi arylations and alkenylations that furnish an array of enantioenriched alpha-arylnitriles and allylic nitriles, respectively. Noteworthy features of this investigation include: the highly enantioselective synthesis of alpha-alkyl-alpha-aryl nitriles that bear secondary alpha-alkyl substituents; the first examples of the use of allcenylzinc reagents in stereoconvergent Negishi reactions of alkyl electrophiles; demonstration of the utility of a new family of ligands for asymmetric Negishi crosscouplings (a bidentate bis(oxazoline), rather than a tridentate pybox); in the case of arylzinc reagents, carbon-carbon bond formation at a remarkably low temperature (-78 degrees C), the lowest reported to date for an enantioselective cross-coupling of an alkyl electrophile; a mechanistic dichotomy between Negishi reactions of an unactivated versus an activated secondary alkyl bromide.
URI
http://pubs.kist.re.kr/handle/201004/67120
ISSN
0002-7863
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