Enantioselective Decarboxylative Arylation of alpha-Amino Acids via the Merger of Photoredox and Nickel Catalysis

Title
Enantioselective Decarboxylative Arylation of alpha-Amino Acids via the Merger of Photoredox and Nickel Catalysis
Authors
최준원Zhiwei ZuoHuan CongWei LiGregory C. FuDavid W. C. MacMillan
Issue Date
2016-02
Publisher
Journal of the American Chemical Society
Citation
VOL 138, NO 6-1835
Abstract
An asymmetric decarboxylative C-sp(3)-C-sp(2) cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant alpha-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents.
URI
http://pubs.kist.re.kr/handle/201004/67123
ISSN
0002-7863
Appears in Collections:
KIST Publication > Article
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