A general, modular method for the catalytic asymmetric synthesis of alkylboronate esters

Title
A general, modular method for the catalytic asymmetric synthesis of alkylboronate esters
Authors
최준원Jens SchmidtAlbert Tianxiang LiuMartin SlusarczykGregory C. Fu
Issue Date
2016-12
Publisher
Science
Citation
VOL 354, NO 6317-1269
Abstract
Alkylboron compounds are an important family of target molecules, serving as useful intermediates, as well as end points, in fields such as pharmaceutical science and organic chemistry. Facile transformation of carbon-boron bonds into a wide variety of carbon-X bonds (where X is, for example, carbon, nitrogen, oxygen, or a halogen), with stereochemical fidelity, renders the generation of enantioenriched alkylboronate esters a powerful tool in synthesis. Here we report the use of a chiral nickel catalyst to achieve stereoconvergent alkyl-alkyl couplings of readily available racemic alpha-haloboronates with organozinc reagents under mild conditions. We demonstrate that this method provides straightforward access to a diverse array of enantioenriched alkylboronate esters, in which boron is bound to a stereogenic carbon, and we highlight the utility of these compounds in synthesis.
URI
http://pubs.kist.re.kr/handle/201004/67124
ISSN
0036-8075
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KIST Publication > Article
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