Iridium-Catalyzed Intermolecular Amidation of sp3 C-H Bonds: Late-Stage Functionalization of an Unactivated Methyl Group
- Iridium-Catalyzed Intermolecular Amidation of sp3 C-H Bonds: Late-Stage Functionalization of an Unactivated Methyl Group
- 강택; 김영찬; 이동군; Zhen Wang; 장석복
- Issue Date
- Journal of the American Chemical Society
- VOL 136, NO 11-4144
- Reported herein is the iridium-catalyzed direct amidation of unactivated sp(3) C-H bonds. With sulfonyl and acyl azides as the amino source, the amidation occurs efficiently under mild conditions over a wide range of unactivated methyl groups with high functional group tolerance. This procedure can be successfully applied for the direct introduction of an amino group into complex compounds and thus can serve as a powerful synthetic tool for late-stage C-H functionalization.
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