Iridium-Catalyzed Intermolecular Amidation of sp3 C-H Bonds: Late-Stage Functionalization of an Unactivated Methyl Group

Title
Iridium-Catalyzed Intermolecular Amidation of sp3 C-H Bonds: Late-Stage Functionalization of an Unactivated Methyl Group
Authors
강택김영찬이동군Zhen Wang장석복
Issue Date
2014-03
Publisher
Journal of the American Chemical Society
Citation
VOL 136, NO 11-4144
Abstract
Reported herein is the iridium-catalyzed direct amidation of unactivated sp(3) C-H bonds. With sulfonyl and acyl azides as the amino source, the amidation occurs efficiently under mild conditions over a wide range of unactivated methyl groups with high functional group tolerance. This procedure can be successfully applied for the direct introduction of an amino group into complex compounds and thus can serve as a powerful synthetic tool for late-stage C-H functionalization.
URI
http://pubs.kist.re.kr/handle/201004/67146
ISSN
0002-7863
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KIST Publication > Article
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