Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp(3) methyl C-H bonds
- Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp(3) methyl C-H bonds
- 강택; 김희정; 김정곤; 장석복
- Issue Date
- Chemical communications
- VOL 50, NO 81-12075
- Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp(3) methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C-H amidation, and LAH reduction was then used to furnish beta-amino alcohol products.
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