Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp(3) methyl C-H bonds

Title
Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp(3) methyl C-H bonds
Authors
강택김희정김정곤장석복
Issue Date
2014-10
Publisher
Chemical communications
Citation
VOL 50, NO 81-12075
Abstract
Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp(3) methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C-H amidation, and LAH reduction was then used to furnish beta-amino alcohol products.
URI
http://pubs.kist.re.kr/handle/201004/67148
ISSN
1359-7345
Appears in Collections:
KIST Publication > Article
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