Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses

Title
Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses
Authors
김수남김진철차민규Spandana Rajendra Kopalli한상윤이상호정민식조재열한창균이승호김시관
Keywords
Panax ginseng; Functional foods; Oxidative stress; autophagy; spermatogenesis; cytokines
Issue Date
2018-01
Publisher
Journal of Functional Foods
Citation
VOL 40-743
Abstract
The effect of Korean red ginseng (KRG; Panax ginseng Meyer) against doxorubicin (DOX)-induced testicular inflammation was investigated. Male Sprague-Dawley rats were treated with DOX (1&#8239; mg&#8239; mL&#8722; 1&#8239; kg&#8722; week&#8722; 1; intra-peritoneally) for 8&#8239; weeks, and KRG water extract (EX1; 100 and EX2; 200&#8239; mg/kg/day; orally) was administered for 9&#8239; weeks starting one week before DOX exposure. The expression levels related to spermatogenesis, inflammatory and autophagy markers were evaluated using western blotting and reverse transcriptase polymerase chain reaction. DOX-induced a significant (p&#8239; <&#8239; .05) alteration in the expression of antioxidation spermatogenesis and sex hormone receptors genes when compared with control groups, which were attenuated with KRG-WE treatment significantly (p&#8239; .05&#8239; ∼&#8239; p&#8239; .01). KRG-WE also ameliorated the DOX-induced alteration in pro-inflammatory cytokines via the mitogen-activated protein kinases/nuclear factor kappa-B pathway and autophagy in the testes of rats. In conclusion, KRG might be used as a functional food for prevention of chemotherapy-induced testicular inflammation.
URI
http://pubs.kist.re.kr/handle/201004/67220
ISSN
1756-4646
Appears in Collections:
KIST Publication > Article
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